Understanding how pancreatic tumors change metabolism to grow and resist treatment
Reprogramming Metabolic Networks in the Tumor Microenvironment
This study is looking at how pancreatic cancer cells change their behavior based on the surrounding cells in the tumor, especially focusing on how certain immune cells help or hinder treatment, with the hope of finding better ways to treat pancreatic cancer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-11093566 on NIH RePORTER |
What this research studies
This research investigates the complex interactions within the pancreatic tumor microenvironment, focusing on how cancer cells adapt their metabolism in response to surrounding stromal and immune cells. By examining the role of tumor-associated macrophages and their influence on nutrient delivery and immune response, the study aims to uncover new therapeutic strategies. The approach includes analyzing metabolic pathways and the effects of specific amino acids on tumor growth and treatment resistance. Patients may benefit from insights that could lead to more effective therapies for pancreatic ductal adenocarcinoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma.
Not a fit: Patients with other types of cancer or those not diagnosed with pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Kerk, Samuel Andrew — Salk Institute for Biological Studies
- Study coordinator: Kerk, Samuel Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.