Understanding how pancreatic cells communicate under high glucose conditions
Official title: Investigation of the Mechanism(s) of Beta and Delta Cell Coordination Under High Glucose
Funded at University of California at Davis · NIH-11036253 · Data updated 2026-11-12
This study is looking at how different cells in the pancreas talk to each other, especially how insulin-producing cells and another type of cell respond when there's a lot of sugar in the blood, which could help us understand diabetes and related conditions better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $42,132 |
| NIH project number | 5F30DK138710-02 |
| Project ID | NIH-11036253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes or congenital hyperinsulinism who experience dysregulated blood sugar levels.
✕Less likely to help
Patients without any pancreatic disorders or those who do not have issues with blood glucose regulation may not benefit from this research.
What this research studies
This research investigates the communication between different types of pancreatic cells, specifically focusing on how insulin-secreting beta cells and somatostatin-secreting delta cells interact when exposed to high glucose levels. The study aims to uncover the mechanisms behind this coordination, which is crucial for maintaining stable blood sugar levels. By examining calcium signaling and cell behavior, researchers hope to identify distinct subpopulations of delta cells and their responses to glucose. This could lead to a better understanding of conditions like diabetes and congenital hyperinsulinism.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and related disorders by enhancing our understanding of blood glucose regulation.
How similar studies have gone: Previous research has shown promising results in understanding pancreatic cell interactions, but this specific approach to studying beta and delta cell coordination under high glucose is relatively novel.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Pourhosseinzadeh, Mohammad S — University of California at Davis
- Study coordinator: Pourhosseinzadeh, Mohammad S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.