Understanding how pancreatic cancer starts and progresses from normal pancreatic tissue
Mechanisms of pancreatic cancer initiation and progression from normal human pancreatic tissue
This study is looking at how pancreatic cancer starts and grows by examining normal pancreatic tissue, and it's for anyone interested in understanding the early changes that happen in the pancreas before cancer develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11015015 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the initiation and progression of pancreatic cancer using normal human pancreatic tissue. By isolating and genetically manipulating primary acinar and ductal cells, the study aims to identify the earliest changes that occur during the development of pancreatic ductal adenocarcinoma (PDAC). The researchers are particularly focused on understanding the process of acinar to ductal metaplasia (ADM), which is a critical early event in PDAC. Through this innovative approach, they hope to uncover the signaling pathways involved, particularly the role of the TGFβ signaling pathway, and how these changes contribute to cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of pancreatic cancer or those diagnosed with conditions that increase their risk for pancreatic cancer.
Not a fit: Patients with advanced pancreatic cancer or those who do not have any risk factors for pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection methods and more effective treatments for pancreatic cancer.
How similar studies have performed: Other research has shown promise in understanding cancer mechanisms using human tissue models, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Wang, Pei — University of Texas Hlth Science Center
- Study coordinator: Wang, Pei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.