Understanding how pancreatic cancer starts and develops
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
This study is looking into how certain changes in our genes and cells can lead to pancreatic cancer, with the hope of finding better ways to spot and treat the disease early on.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10927295 on NIH RePORTER |
What this research studies
This research investigates the genetic and cellular origins of pancreatic cancer, specifically focusing on how certain mutations and cell types contribute to the disease's initiation. By utilizing advanced techniques like CRISPR, the study aims to explore the transformation of acinar cells into cancerous cells through a process called Acinar to Ductal Metaplasia (ADM). The research will analyze the role of tumor suppressor genes and oncogenes in this process, which could lead to better early diagnosis and treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for pancreatic cancer, such as those with a family history of the disease or chronic pancreatitis.
Not a fit: Patients with advanced pancreatic cancer or those who do not have any genetic predisposition to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and treatment of pancreatic cancer.
How similar studies have performed: Previous research has shown promise in understanding pancreatic cancer through genetic studies, but this specific approach using CRISPR and focusing on acinar cells is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Attardi, Laura D — Stanford University
- Study coordinator: Attardi, Laura D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.