Understanding how pancreatic cancer precursors evolve and can be treated.
Interrogation of the Impact of Selection on the Evolution of Human Pancreatic Cancer Precursor Lesions
['FUNDING_U01'] · JOHNS HOPKINS UNIVERSITY · NIH-10911181
This study is looking at how certain precancerous growths in the pancreas change over time, using tissue samples to find out what makes them develop, with the hope of improving early detection and treatment for pancreatic cancer.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10911181 on ClinicalTrials.gov |
What this research studies
This research investigates the evolution of precancerous pancreatic lesions known as intraductal papillary mucinous neoplasms (IPMNs). By analyzing tissue samples and organoid cultures, the team aims to identify the molecular features and selective pressures that influence the progression of these lesions. The study employs advanced genomic techniques, including whole genome sequencing and RNA-sequencing, to uncover the genetic changes that occur over time. This comprehensive approach may lead to better detection and treatment strategies for pancreatic cancer at its earliest stages.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with intraductal papillary mucinous neoplasms (IPMNs) or those at high risk for developing pancreatic cancer.
Not a fit: Patients with advanced pancreatic cancer or those without precancerous lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and treatment of pancreatic cancer, potentially saving lives.
How similar studies have performed: Previous research has shown promise in understanding the genetic evolution of cancer precursors, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOD, LAURA DELONG — JOHNS HOPKINS UNIVERSITY
- Study coordinator: WOOD, LAURA DELONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.