Understanding how pancreatic cancer cells resist treatment
Stromal metabolism promotes therapeutic resistance in pancreatic cancer
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10820476
This study is looking at how pancreatic cancer cells manage to survive and resist treatment, and it aims to find new ways to help improve outcomes for patients by targeting the processes that help these cells thrive.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10820476 on ClinicalTrials.gov |
What this research studies
This research investigates the metabolic processes that allow pancreatic cancer cells to survive and resist therapies. It focuses on how these cancer cells interact with their surrounding environment, particularly the non-cancerous cells and the extracellular matrix, which can hinder effective treatment. By exploring new therapeutic strategies that target these metabolic pathways, the research aims to improve treatment outcomes for patients with pancreatic ductal adenocarcinoma. The study involves both laboratory experiments and clinical trials to evaluate the effectiveness of these new approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who have not responded well to existing therapies.
Not a fit: Patients with early-stage pancreatic cancer or those who have not been diagnosed with pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting metabolic pathways in cancer treatment, indicating that this approach could lead to significant advancements in managing pancreatic cancer.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LYSSIOTIS, COSTAS ANDREAS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LYSSIOTIS, COSTAS ANDREAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer