Understanding how pancreatic cancer cells interact with surrounding fibroblasts
Pancreatic cancer-associated fibroblasts: function, detection, and regulation
This study is looking at how certain cells in the pancreas, called cancer-associated fibroblasts, affect pancreatic cancer and hopes to find new ways to improve treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11101279 on NIH RePORTER |
What this research studies
This research investigates the role of cancer-associated fibroblasts (CAFs) in pancreatic cancer, focusing on how they contribute to the tumor environment. By examining the extracellular matrices produced by these fibroblasts, the study aims to uncover mechanisms that could either promote or inhibit cancer growth. The approach includes analyzing signaling pathways and cellular interactions that could lead to new therapeutic strategies to enhance the anti-tumor effects of CAFs. Patients may benefit from insights that could improve treatment options for pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic cancer who may benefit from novel treatment strategies targeting the tumor microenvironment.
Not a fit: Patients with non-cancerous conditions or those with advanced-stage pancreatic cancer where treatment options are limited may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the body's natural defenses against pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in targeting the tumor microenvironment in other cancers, suggesting potential for success in this area as well.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Cukierman, Edna — Research Inst of Fox Chase Can Ctr
- Study coordinator: Cukierman, Edna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.