Understanding how pancreatic cancer adapts and resists treatment
Mechanisms of Epigenetic Plasticity in PDAC
This study is looking at how pancreatic cancer cells can change to survive treatment, and it's for anyone affected by this tough-to-treat cancer, as it hopes to find new ways to make treatments work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11060882 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the adaptability of pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer. It focuses on how certain cancer cells can change their characteristics to survive despite treatments aimed at targeting specific mutations. By using advanced genetic models, the study aims to uncover the cellular and molecular factors that allow these cancer cells to resist therapies, particularly those targeting the Yap protein. The findings could lead to new treatment strategies that effectively combat this deadly disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with advanced pancreatic ductal adenocarcinoma who have not responded to standard treatments.
Not a fit: Patients with early-stage pancreatic cancer or those whose cancer is not driven by Kras mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for pancreatic cancer, improving survival rates and treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding cancer adaptability, but this specific approach focusing on Yap in PDAC is relatively novel.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Yi, Chunling — Georgetown University
- Study coordinator: Yi, Chunling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.