Understanding how pain signals affect tooth and jaw health
Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling
This study, led by Dr. Chung, is looking at how pain-sensing nerves in your mouth affect chronic pain and the health of your jawbone, with the hope that by reducing these pain signals, it can help ease your pain and improve your jawbone health during dental problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10876435 on NIH RePORTER |
What this research studies
This research investigates the role of pain-sensing nerves in the mouth and their impact on chronic pain and the health of jawbone. The principal investigator, Dr. Chung, aims to understand how these nerves can both signal pain and help regulate the body's response to injury or infection. By silencing these pain signals over time, the research seeks to determine if it can alleviate chronic pain and reverse harmful changes in the brain associated with it. Additionally, the study will explore how these nerves influence the remodeling of the jawbone during dental issues like infections or orthodontic treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic orofacial pain and those with periodontal disease.
Not a fit: Patients without chronic pain or dental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain and improved dental health.
How similar studies have performed: Previous research has shown promising results in understanding the role of nociceptors in pain management, suggesting potential for success in this area.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Chung, Man-Kyo — University of Maryland Baltimore
- Study coordinator: Chung, Man-Kyo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.