Understanding how pain sensitivity and sleep issues affect treatment outcomes in knee osteoarthritis patients
Official title: Central Sensitization and Sleep Disturbance as Predictors of Treatment Outcomes in Patients with Knee Osteoarthritis
Funded at Johns Hopkins University · NIH-10888200 · Data updated 2026-11-12
This study is looking at how increased pain sensitivity and sleep problems affect treatment options for people with knee osteoarthritis, so we can find the best ways to help you feel better and sleep well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $383,980 |
| NIH project number | 5R01AR079792-04 |
| Project ID | NIH-10888200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults suffering from knee osteoarthritis who experience chronic pain and sleep disturbances.
✕Less likely to help
Patients with knee osteoarthritis who do not have issues with pain sensitivity or sleep disturbances may not benefit from this research.
What this research studies
This research investigates the relationship between central sensitization, which is heightened pain sensitivity, and sleep disturbances in patients with knee osteoarthritis (KOA). It aims to understand how these factors influence the effectiveness of various treatment options, including behavioral therapies and medications. By analyzing patient responses to different interventions, the study seeks to improve treatment selection and outcomes for individuals suffering from KOA. Patients may be assessed for their pain levels and sleep quality to tailor interventions that best suit their needs.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with knee osteoarthritis, improving their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of central sensitization and sleep disturbances in chronic pain conditions, indicating that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Campbell, Claudia Michelle — Johns Hopkins University
- Study coordinator: Campbell, Claudia Michelle
Related research
Other NIH-funded projects on the same topics.
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Aims to map inflammation across the body and brain in people with knee osteoarthritis using advanced imaging to help explain and improve pain and treatment.
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Determinants of rapid knee osteoarthritis progression using radiograph features
A patient-friendly look at how knees with osteoarthritis may progress more quickly, using advanced X-ray measurements to identify who is at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.