Understanding how pain-sensing channels in nerves work
Official title: Structural Basis of Nociceptor Channel TRPM3 gating and pharmacology
Funded at Van Andel Research Institute · NIH-10909286 · Data updated 2026-11-12
This study is looking at a special channel in our bodies that helps us feel pain from things like heat and pressure, and it's trying to find new ways to help manage that pain better for people who experience it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $740,104 |
| NIH project number | 5R01NS129804-02 |
| Project ID | NIH-10909286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic pain or conditions that involve nociceptive signaling.
✕Less likely to help
Patients with pain that is not related to the mechanisms studied, such as neuropathic pain, may not benefit from this research.
What this research studies
This research investigates the TRPM3 channel, a key player in how our body senses pain from harmful stimuli like heat and pressure. By studying how this channel operates and responds to various triggers, the research aims to uncover new ways to manage pain. The approach includes using advanced techniques to analyze the structure and function of TRPM3, which could lead to the development of new pain relief methods. Patients may benefit from insights that could improve pain management strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pain relief that are more effective and targeted.
How similar studies have gone: Previous research has shown promise in targeting similar pain pathways, indicating that this approach could yield significant advancements.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Du, Juan — Van Andel Research Institute
- Study coordinator: Du, Juan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.