Understanding how pain is detected by nerve cells
The cellular and molecular mechanisms underlying nociception and pain
This study is looking at how our bodies feel pain by focusing on special nerve cells that detect harmful things like heat or pressure, and it aims to find new ways to help manage pain better for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11009676 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms that allow our bodies to perceive pain, focusing on specialized nerve cells called nociceptors. By examining how these nociceptors detect harmful stimuli, such as extreme temperatures or pressure, the research aims to uncover new insights into pain perception. The study utilizes advanced techniques like single-cell RNA sequencing to identify different types of nociceptors and their roles in pain detection. This knowledge could lead to the development of new pain management therapies that target these specific nerve cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain conditions or those with heightened sensitivity to pain.
Not a fit: Patients with pain that is not related to nociceptive mechanisms, such as neuropathic pain, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for pain that are more effective and have fewer side effects than current options.
How similar studies have performed: Previous research has shown promising results in understanding nociceptor function, indicating that this approach has the potential for significant breakthroughs in pain management.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Sharma, Nikhil — Columbia University Health Sciences
- Study coordinator: Sharma, Nikhil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.