Understanding how pain affects opioid use differently in men and women
Sex-specific mechanisms underlying the effects of pain on opioid seeking
This study looks at how men and women experience pain differently and how that affects their use of opioid medications, especially for those dealing with chronic pain, to help find better ways to manage pain for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10873204 on NIH RePORTER |
What this research studies
This research investigates the differences between men and women in how pain influences the use of opioid medications. It aims to understand the biological and behavioral mechanisms that lead to higher rates of opioid misuse in men compared to women, particularly in the context of chronic pain. By using preclinical models, the study examines how inflammatory pain affects opioid intake and the potential neurobiological changes that occur. The findings could provide insights into more effective pain management strategies tailored to different sexes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain who are prescribed opioid medications, particularly those over the age of 21.
Not a fit: Patients who do not experience chronic pain or are not prescribed opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies that reduce the risk of opioid misuse, particularly in men.
How similar studies have performed: Previous research has indicated sex differences in opioid misuse, suggesting that this approach has potential for significant findings.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Moron-Concepcion, Jose a — Washington University
- Study coordinator: Moron-Concepcion, Jose a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.