Understanding how PACAP helps newborns breathe at birth
Regulation of PACAP expression and its role in protecting early neonatal respiration.
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF VIRGINIA · NIH-10997466
This study is looking at how a special protein called PACAP helps newborns start breathing and aims to find ways to prevent breathing problems in infants by exploring how this protein works in the brain.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10997466 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific neuropeptide, PACAP, in regulating the initiation of breathing in newborns. It focuses on the neural circuitry and molecular signals involved in this critical process, particularly in the brainstem. By studying how PACAP expression changes at birth and its effects on respiratory function, the research aims to uncover mechanisms that could prevent breathing-related issues in infants. The approach includes genetic analysis and observation of neonatal mice to understand the implications of PACAP on respiratory health.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and infants, particularly those at risk for respiratory issues or SIDS.
Not a fit: Patients who are older than 21 years or those without respiratory complications are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing respiratory complications in newborns, potentially reducing the risk of sudden infant death syndrome (SIDS).
How similar studies have performed: Previous research has indicated a link between PACAP variants and increased incidence of SIDS, suggesting that this approach may build on established findings in the field.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLEMENTS, RACHEL — UNIVERSITY OF VIRGINIA
- Study coordinator: CLEMENTS, RACHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.