Understanding how P53 pathways affect malaria in children
Evaluating the role of P53 pathways in malaria
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11014948
This study is looking at how a protein called P53 helps control inflammation from malaria in kids who get sick with it often, with the hope of finding new treatments to make their symptoms less severe and help them feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11014948 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the P53 protein in managing inflammation caused by malaria, particularly in children who experience multiple malaria infections each year. By studying how P53 influences the immune response, the researchers aim to develop new therapies that can reduce the severity of malaria symptoms and improve patient outcomes. The approach includes analyzing blood samples from children to understand the relationship between P53 levels and malaria-related inflammation. The ultimate goal is to find ways to enhance the body's natural defenses against malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are at risk of malaria infections.
Not a fit: Patients who are not children or those who do not live in malaria-endemic regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the severity and mortality of malaria in children.
How similar studies have performed: Previous research has shown promising results in using P53 to modulate inflammation and reduce parasite burden in malaria models, indicating potential for success in this approach.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAN, TUAN MANH — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: TRAN, TUAN MANH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.