Understanding how p53 mutations affect cancer development
Cell lineage determinants of p53-driven fate outcomes in vivo
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10983319
This study is looking at how changes in the p53 gene, which is often altered in cancer, affect how cancer grows, using mice to help us learn more about it so we can find better ways to treat cancers linked to these gene changes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10983319 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the p53 gene, which is often mutated in cancers, to understand how these mutations influence cancer progression. By studying both the normal (wild-type) and mutated forms of p53 in mouse models, the research aims to uncover how these variations affect cell behavior and fate in different tissues. The approach involves examining the gene expression controlled by p53 to determine its tumor-suppressing and oncogenic functions. Insights gained from this research could lead to better understanding and treatment strategies for cancers associated with p53 mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers that have known p53 mutations.
Not a fit: Patients with cancers unrelated to p53 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers driven by p53 mutations.
How similar studies have performed: Previous research has shown promising results in understanding p53 functions, indicating that this approach has potential for significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANFREDI, JAMES J — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: MANFREDI, JAMES J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers