Understanding how p53 family genes affect lung cancer metabolism
Project 1
['FUNDING_P01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-11128781
This research explores how a group of genes called the p53 family influences the way lung cancer cells use energy, hoping to find new ways to fight the disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11128781 on ClinicalTrials.gov |
What this research studies
Lung cancer often has changes in a gene called p53, which is part of a larger family including p63 and p73. These genes are important for controlling how cells grow and how they use energy, and their functions can become complex due to different versions of these genes. When p53 is mutated in cancer, it can interfere with the helpful actions of p63 and p73, potentially making the cancer worse. This project aims to understand these complex interactions and how they affect the metabolism of lung cancer cells. By uncovering these metabolic weaknesses, we hope to discover new targets for more effective lung cancer treatments.
Who could benefit from this research
Good fit: This foundational research is for patients with lung cancer, especially those whose tumors have mutations in the p53 family of genes.
Not a fit: Patients with cancers unrelated to lung cancer or those without p53 family gene mutations may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatment strategies that specifically target the energy pathways of lung cancer cells, potentially improving outcomes for patients.
How similar studies have performed: Previous work has shown that p53-deficient and mutant tumors can be metabolically reprogrammed, suggesting a promising avenue for this approach.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLORES, ELSA R — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: FLORES, ELSA R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers