Understanding how p53 and MYC affect cell responses to DNA damage
Official title: The roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stress
Funded at University of Minnesota · NIH-11001973 · Data updated 2026-11-12
This study is looking at how two important proteins, p53 and MYC, affect how cells deal with DNA damage, which is important for understanding cancer, and by watching these proteins in action, the researchers hope to find better ways to treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $291,834 |
| NIH project number | 5R01GM149666-03 |
| Project ID | NIH-11001973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers related to p53 and MYC mutations, particularly breast cancer patients.
✕Less likely to help
Patients with cancers not associated with p53 or MYC mutations may not benefit from this research.
What this research studies
This research investigates how the proteins p53 and MYC influence how cells respond to DNA damage, which is crucial for cancer development. By observing individual cells over time, the study aims to uncover how variations in the levels of these proteins lead to different outcomes, such as cell death or survival. The researchers will use advanced imaging techniques to track these proteins and analyze their effects on cell behavior in response to stress. This knowledge could help improve cancer therapies by targeting these pathways more effectively.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by understanding how to manipulate cell responses to DNA damage.
How similar studies have gone: Previous research has shown that understanding the dynamics of cellular responses to stress can lead to significant advancements in cancer treatment strategies.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Batchelor, Eric — University of Minnesota
- Study coordinator: Batchelor, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.