Understanding how P2X7 receptors work and creating new therapies for heart disease
Elucidation of P2X7 Receptor Signaling and Development of Novel Small Molecule and Aptamer Ligand Therapies
This study is looking at a specific part of our cells that plays a big role in inflammation and heart health, with the goal of creating new treatments that could help prevent heart problems like coronary artery disease, so patients can enjoy better heart health and less inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10472269 on NIH RePORTER |
What this research studies
This research investigates the P2X7 receptor, a key player in inflammation and cardiovascular health, to develop new small molecule and aptamer therapies. By studying the receptor's structure and signaling pathways, the research aims to identify ways to inhibit its activity, which could prevent conditions like coronary artery disease. The approach includes using advanced imaging techniques to visualize the receptor at an atomic level, providing insights that could lead to effective treatments. Patients may benefit from novel therapies that target this receptor to reduce inflammation and improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for coronary artery disease or those with inflammatory conditions affecting the cardiovascular system.
Not a fit: Patients with non-cardiovascular related health issues or those not experiencing inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent coronary artery disease and improve cardiovascular health.
How similar studies have performed: Other research has shown promise in targeting P2X receptors for therapeutic purposes, but this specific approach is novel and has not yet been fully tested.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mansoor, Steven Elias — Oregon Health & Science University
- Study coordinator: Mansoor, Steven Elias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.