Understanding how p27 influences stem cell behavior and development
Novel roles for p27 as transcriptional co-regulator of cJun in stem cells and development
This study is looking at how a protein called p27 helps control the behavior of stem cells, which are important for tissue growth and healing, by seeing how it interacts with another protein, cJun, to manage gene activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10906267 on NIH RePORTER |
What this research studies
This research investigates the role of the protein p27 in regulating stem cell behavior and development. It focuses on how specific modifications of p27 can affect its interactions with other proteins, particularly cJun, which is involved in gene regulation. By examining how p27 and cJun work together to activate or repress genes, the research aims to uncover mechanisms that control stem cell growth and differentiation. This could provide insights into how stem cells contribute to tissue development and regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who are interested in stem cell therapies or have conditions related to stem cell function.
Not a fit: Patients with conditions unrelated to stem cell biology or those under 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing stem cell therapies and improving tissue regeneration.
How similar studies have performed: Other research has shown promising results in understanding the roles of proteins like p27 in stem cell regulation, indicating that this approach has potential for success.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Slingerland, Joyce Marie — Georgetown University
- Study coordinator: Slingerland, Joyce Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.