Understanding how p120RasGAP protein regulates blood vessel formation
Official title: Inter-Domain Regulation of p120RasGAP
Funded at Yale University · NIH-11017043 · Data updated 2026-11-12
This study is looking at a protein called p120RasGAP that helps control how blood vessels form and send signals, with the goal of finding new ways to treat people with vascular diseases like arteriovenous malformations.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL167578-03 |
| Project ID | NIH-11017043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with vascular disorders such as capillary malformation-arteriovenous malformation syndromes or vein of Galen malformations.
✕Less likely to help
Patients with vascular disorders unrelated to the mechanisms of p120RasGAP may not receive any benefit from this research.
What this research studies
This research investigates the p120RasGAP protein, which plays a crucial role in regulating blood vessel formation and signal transduction. The study aims to understand how different parts of this protein interact and affect its function, particularly in relation to vascular diseases like arteriovenous malformations. By analyzing the protein's structure and biochemical properties, the research seeks to uncover mechanisms that could lead to new therapeutic strategies for patients with vascular disorders. Patients may benefit from insights gained into how these proteins can be targeted for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for vascular diseases that affect blood vessel formation.
How similar studies have gone: Previous research has shown that understanding the regulation of similar proteins can lead to significant advancements in treating vascular diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Paul, Maxum — Yale University
- Study coordinator: Paul, Maxum
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.