Understanding how P-glycoprotein affects drug transport
Official title: Inhibition or evasion of P-glycoprotein-mediated drug transport
Funded at Scripps Research Institute, the · NIH-11088932 · Data updated 2026-11-12
This study is looking at how a protein called P-glycoprotein affects the way certain medications work in the body, with the goal of finding ways to make these drugs more effective for people who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 10, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $497,527 |
| NIH project number | 5R01GM148675-03 |
| Project ID | NIH-11088932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who are undergoing treatment for conditions affected by drug resistance, such as cancer or HIV/AIDS.
✕Less likely to help
Patients who are not currently taking medications that are affected by P-glycoprotein may not benefit from this research.
What this research studies
This research investigates the role of P-glycoprotein (Pgp) in transporting drugs out of cells, which can impact how effective these drugs are in treating diseases. By examining the molecular interactions between Pgp and various drugs, the research aims to find ways to inhibit or evade Pgp's action, potentially improving drug bioavailability and efficacy. The study includes several specific aims that focus on understanding how Pgp interacts with different substances, which could lead to the development of new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved drug treatments for patients by enhancing the effectiveness of medications that are currently limited by Pgp-mediated resistance.
How similar studies have gone: Previous research has shown promise in understanding drug interactions with P-glycoprotein, indicating that this approach could lead to significant advancements in treatment options.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Zhang, Qinghai — Scripps Research Institute, the
- Study coordinator: Zhang, Qinghai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.