Understanding how P. gingivalis survives inside human gum cells
Turning on Persistence: Novel Molecular Determinants that Underpin P. gingivalis Intracellular Survival In Epithelial Cells
This study looks at how a type of bacteria that can cause gum disease, called Porphyromonas gingivalis, manages to live and grow inside the cells of your gums, helping us understand how it avoids your body's defenses and could lead to new ways to treat gum problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10899633 on NIH RePORTER |
What this research studies
This research investigates how the bacteria Porphyromonas gingivalis can survive and multiply within human gingival epithelial cells, which are crucial for oral health. The study focuses on the interactions between these bacteria and the cells, particularly how P. gingivalis manipulates cellular processes to evade the immune response. By examining the role of specific molecules involved in the bacteria's survival, the research aims to uncover new insights into the mechanisms of infection and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with periodontal disease or those experiencing oral health issues related to P. gingivalis infection.
Not a fit: Patients without any oral health issues or those not infected with P. gingivalis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for periodontal disease and improve oral health outcomes.
How similar studies have performed: Other research has shown success in understanding bacterial interactions with host cells, making this approach promising but still novel in the context of P. gingivalis.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Yilmaz, Ozlem — Medical University of South Carolina
- Study coordinator: Yilmaz, Ozlem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.