Understanding how oxytocin affects pain recovery after surgery
Creating PK/PD models for oxytocin action in humans and bridging to intranasal delivery
This study is looking at how the hormone oxytocin can help people recover from surgery and manage pain better, especially by using a nasal spray, while also considering how things like age, sex, and weight might change how well it works for different individuals.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-11074070 on NIH RePORTER |
What this research studies
This research investigates how oxytocin, a hormone known for its role in childbirth and social bonding, can influence recovery from surgery and pain management. By creating models to understand how oxytocin is absorbed and distributed in the body, the study aims to identify the best ways to administer this hormone, particularly through intranasal delivery. The research will also explore how individual factors like age, sex, and weight may affect the hormone's effectiveness in alleviating pain. Ultimately, the goal is to enhance recovery outcomes for patients undergoing surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals scheduled for surgery who may experience acute or chronic pain post-operation.
Not a fit: Patients who are not undergoing surgery or those with conditions unrelated to pain management may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies and faster recovery times for surgical patients.
How similar studies have performed: Previous research has shown promising results in using oxytocin for pain management in animal models, but this approach is still being tested in humans.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Eisenach, James — Wake Forest University Health Sciences
- Study coordinator: Eisenach, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.