Understanding how oxygen affects airway cells in premature infants
Cellular Senescence in Neonatal Airways
This study is looking at how moderate oxygen levels affect lung cells in premature babies, especially how some of these cells can become old and cause breathing problems, and it’s testing new treatments that might help improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10879101 on NIH RePORTER |
What this research studies
This research investigates the impact of moderate oxygen levels on airway smooth muscle cells in premature infants, focusing on a phenomenon called cellular senescence. It aims to uncover how these senescent cells contribute to airway hyperresponsiveness and fibrosis, which can lead to breathing difficulties. The study employs both human fetal lung samples and neonatal mouse models to explore the mechanisms involved and tests potential treatments using senolytic drugs that target and eliminate these harmful cells. By understanding these processes, the research seeks to develop better therapeutic strategies for vulnerable infants.
Who could benefit from this research
Good fit: Ideal candidates for this research include premature infants who are exposed to moderate oxygen levels and may be at risk for airway hyperresponsiveness and related conditions.
Not a fit: Patients who are not premature or do not have airway diseases related to oxygen exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for airway diseases in premature infants, potentially reducing the risk of long-term respiratory issues.
How similar studies have performed: Other research has shown promising results in targeting cellular senescence in various conditions, suggesting that this approach may be effective in treating airway diseases as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Prakash, Y. S. — Mayo Clinic Rochester
- Study coordinator: Prakash, Y. S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.