Understanding how oxidative stress causes genetic instability
Mechanistic insight into oxidative stress-mediated genome instability
This study looks at how things like air pollution and sunlight can harm our cells and lead to DNA damage, and it aims to understand how our bodies fix this damage, which could help improve treatments for diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10893987 on NIH RePORTER |
What this research studies
This research investigates how oxidative stress, which can result from environmental factors like air pollution and UV light, leads to genetic instability in cells. It focuses on the mechanisms that cause DNA damage and how this damage is repaired through a process called base excision repair. By studying the role of specific proteins involved in this repair process, the research aims to uncover the links between oxidative stress and various diseases, including cancer. Patients may benefit from insights that could lead to improved treatments or preventive strategies for conditions related to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of cancer or those exposed to high levels of oxidative stress due to environmental factors.
Not a fit: Patients with genetic conditions unrelated to oxidative stress or DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for cancers and other diseases linked to DNA damage.
How similar studies have performed: Previous research has shown that understanding oxidative stress and DNA repair mechanisms can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Fouquerel, Elise — University of Pittsburgh at Pittsburgh
- Study coordinator: Fouquerel, Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.