Understanding how oxidative stress and cell death affect lung cancer
Official title: Dissecting the role of redox homeostasis and ferroptosis in lung cancer
Funded at New York University School of Medicine · NIH-11066526 · Data updated 2026-11-12
This study is looking at how lung cancer cells deal with stress in their environment and whether this stress can cause them to die, which might help us find better ways to treat lung cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 4, 2023 |
| Project end | April 3, 2026 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30CA275258-03 |
| Project ID | NIH-11066526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lung cancer who may benefit from novel therapeutic approaches targeting oxidative stress.
✕Less likely to help
Patients with non-cancerous conditions or those whose lung cancer is not responsive to oxidative stress-based therapies may not benefit from this research.
What this research studies
This research investigates the role of oxidative stress and a specific type of cell death called ferroptosis in lung cancer. It aims to understand how cancer cells manage oxidative stress and whether this stress can lead to cell death, potentially offering new therapeutic strategies. The study will explore the mechanisms behind lipid peroxidation and how it may be exploited to enhance the effectiveness of existing cancer treatments. By examining these processes, the research seeks to identify new ways to target lung cancer cells more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for lung cancer patients by harnessing the mechanisms of ferroptosis.
How similar studies have gone: Previous research has shown promising results in targeting ferroptosis in cancer cells, indicating that this approach may hold significant therapeutic potential.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wu, Katherine — New York University School of Medicine
- Study coordinator: Wu, Katherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.