Understanding how oxidative stress affects heart function through calcium channels
Official title: New mechanisms of cardiac ryanodine receptor dysfunction during oxidative stress: the role of intersubunit cross-linking
Funded at Loyola University Chicago · NIH-11019605 · Data updated 2026-11-12
This study is looking at how a specific part of heart cells, called the ryanodine receptor, is affected by stress in the body, which can mess with how calcium is released and cause heart problems, with the hope of finding new ways to help people with heart issues like heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $634,183 |
| NIH project number | 1R01HL176568-01 |
| Project ID | NIH-11019605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac diseases, particularly those experiencing conditions related to oxidative stress and calcium dysregulation.
✕Less likely to help
Patients with non-cardiac conditions or those whose heart issues are unrelated to oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of the ryanodine receptor (RyR) in heart function, particularly how oxidative stress impacts calcium release, which is crucial for heart contractions. The study aims to identify specific cysteine residues in the RyR that are affected by oxidative stress, leading to dysfunction in calcium homeostasis. By using a transgenic mouse model, researchers will explore the mechanisms behind this dysfunction and how it relates to common cardiac conditions like myocardial infarction. The ultimate goal is to pave the way for new therapeutic strategies to improve heart health in patients suffering from ischemic heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of serious cardiac events in patients with heart disease.
How similar studies have gone: Previous research has shown promising results in understanding calcium dysregulation in cardiac diseases, suggesting that this approach could yield significant insights.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Zima, Aleksey V — Loyola University Chicago
- Study coordinator: Zima, Aleksey V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.