Understanding how oxidative stress affects heart function through calcium channels
New mechanisms of cardiac ryanodine receptor dysfunction during oxidative stress: the role of intersubunit cross-linking
This study is looking at how a specific part of heart cells, called the ryanodine receptor, is affected by stress in the body, which can mess with how calcium is released and cause heart problems, with the hope of finding new ways to help people with heart issues like heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-11019605 on NIH RePORTER |
What this research studies
This research investigates the role of the ryanodine receptor (RyR) in heart function, particularly how oxidative stress impacts calcium release, which is crucial for heart contractions. The study aims to identify specific cysteine residues in the RyR that are affected by oxidative stress, leading to dysfunction in calcium homeostasis. By using a transgenic mouse model, researchers will explore the mechanisms behind this dysfunction and how it relates to common cardiac conditions like myocardial infarction. The ultimate goal is to pave the way for new therapeutic strategies to improve heart health in patients suffering from ischemic heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac diseases, particularly those experiencing conditions related to oxidative stress and calcium dysregulation.
Not a fit: Patients with non-cardiac conditions or those whose heart issues are unrelated to oxidative stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of serious cardiac events in patients with heart disease.
How similar studies have performed: Previous research has shown promising results in understanding calcium dysregulation in cardiac diseases, suggesting that this approach could yield significant insights.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Zima, Aleksey V — Loyola University Chicago
- Study coordinator: Zima, Aleksey V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.