Understanding how oxidative stress affects gum inflammation
Redox Regulation of Gingival Inflammation
This study is looking at how certain molecules in your body, called reactive oxygen species, affect inflammation in gum disease, with the hope of finding new ways to treat this common issue and improve your overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10746009 on NIH RePORTER |
What this research studies
This research investigates the role of reactive oxygen species (ROS) in regulating inflammation in periodontal diseases, which are common infections affecting the gums. The study aims to understand how these molecules influence immune responses in the oral cavity, particularly focusing on neutrophils and macrophages. By examining the balance of ROS levels, the research seeks to determine how they can either exacerbate or help control inflammation in gum tissues. Patients may benefit from insights that could lead to new treatments for gum disease and its systemic effects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from periodontal diseases or those with autoimmune conditions that may affect gum health.
Not a fit: Patients without any gum disease or those not experiencing inflammation in the oral cavity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease and potentially reduce the risk of related systemic health issues.
How similar studies have performed: Previous research has shown that understanding the role of oxidative stress in inflammation can lead to significant advancements in treatment strategies for various inflammatory conditions.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Bagaitkar, Juhi — Research Inst Nationwide Children's Hosp
- Study coordinator: Bagaitkar, Juhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.