Understanding how oxidative stress affects DNA replication and stability
Official title: Investigating the Cellular Impact of 8-oxo-Guanine on DNA Replication and Genome Stability
Funded at University of Kansas Medical Center · NIH-10977080 · Data updated 2026-11-12
This study is looking at how oxidative stress can harm DNA, especially a specific type of damage called 8-oxodeoxyguanosine, using a new method that lets researchers control this damage in living cells, which could help us understand how it relates to cancer and aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | November 1, 2023 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00ES033771-04 |
| Project ID | NIH-10977080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for conditions associated with oxidative stress, including certain cancers and age-related diseases.
✕Less likely to help
Patients with conditions unrelated to oxidative stress or DNA damage may not benefit from this research.
What this research studies
This research investigates the effects of oxidative stress on DNA, particularly focusing on a specific DNA damage known as 8-oxodeoxyguanosine (8oxoG). The team has developed a novel method using a chemoptogenetic system that allows for precise control over the production of 8oxoG in living cells. By using a specialized peptide that binds to a photosensitizer dye, they can generate singlet oxygen, which specifically damages guanine in DNA. This approach aims to provide insights into how oxidative stress impacts DNA replication and contributes to genomic instability, which is crucial for understanding cancer development and aging.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating conditions related to DNA damage, such as cancer.
How similar studies have gone: Previous research has shown promising results in understanding DNA damage mechanisms, but this specific approach using the chemoptogenetic system is relatively novel.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Barnes, Ryan P — University of Kansas Medical Center
- Study coordinator: Barnes, Ryan P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.