Understanding how oxidative stress affects DNA repair mechanisms
Official title: Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair
Funded at Univ of Arkansas for Med Scis · NIH-10805521 · Data updated 2026-11-12
This study looks at how things like pollution and radiation can harm our DNA and cause problems like cancer and aging, focusing on a specific type of damage, and it aims to understand how our bodies fix this damage to help improve health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | March 8, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00ES029572-03 |
| Project ID | NIH-10805521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancer or neurodegenerative disorders, particularly those with a history of exposure to oxidative stressors.
✕Less likely to help
Patients with conditions unrelated to oxidative stress or DNA repair mechanisms may not benefit from this research.
What this research studies
This research investigates how oxidative stress, caused by factors like pollution and radiation, damages DNA and leads to mutations. It focuses on a specific type of DNA damage known as 8-oxoG, which can result in double strand breaks and genomic instability. By studying the role of DNA polymerases in repairing this damage, the research aims to uncover the mechanisms behind cancer and aging. The approach includes advanced techniques like pH jump crystallography to visualize the repair processes at a molecular level.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cancer and age-related diseases by improving our understanding of DNA repair mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Jamsen, Joonas — Univ of Arkansas for Med Scis
- Study coordinator: Jamsen, Joonas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.