Understanding how oxidative stress affects DNA repair mechanisms
Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair
['FUNDING_OTHER'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-10805521
This study looks at how things like pollution and radiation can harm our DNA and cause problems like cancer and aging, focusing on a specific type of damage, and it aims to understand how our bodies fix this damage to help improve health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-10805521 on ClinicalTrials.gov |
What this research studies
This research investigates how oxidative stress, caused by factors like pollution and radiation, damages DNA and leads to mutations. It focuses on a specific type of DNA damage known as 8-oxoG, which can result in double strand breaks and genomic instability. By studying the role of DNA polymerases in repairing this damage, the research aims to uncover the mechanisms behind cancer and aging. The approach includes advanced techniques like pH jump crystallography to visualize the repair processes at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancer or neurodegenerative disorders, particularly those with a history of exposure to oxidative stressors.
Not a fit: Patients with conditions unrelated to oxidative stress or DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cancer and age-related diseases by improving our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAMSEN, JOONAS — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: JAMSEN, JOONAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers