Understanding how oxidative stress affects bacteria and human cells
Structural systems biology of microenvironmental oxidative stress and synthetic biology intervention
This study is looking at how stress affects bacteria and human cells to understand why some proteins don't work properly when they're under pressure, which could help us find new ways to diagnose and treat issues related to aging and radiation damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11097383 on NIH RePORTER |
What this research studies
This research investigates the effects of oxidative stress on bacteria and human cells to uncover how certain proteins malfunction under stress conditions. By using a structural systems biology approach, the study aims to create detailed models that simulate oxidative damage and its impact on cellular metabolism. The research will involve advanced techniques like proteomics and metabolomics to validate predictions and identify potential targets for diagnosing and treating conditions related to oxidative stress, such as radiation toxicity and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by oxidative stress-related conditions, such as those undergoing radiation therapy or experiencing metabolic dysfunction.
Not a fit: Patients with conditions unrelated to oxidative stress or those not experiencing cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for conditions associated with oxidative stress.
How similar studies have performed: Previous research has shown promise in understanding oxidative stress through similar proteomic and systems biology approaches, suggesting potential for success in this study.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Chang, Roger Larken — Albert Einstein College of Medicine
- Study coordinator: Chang, Roger Larken
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.