Understanding how oxidative stress affects bacteria and human cells
Official title: Structural systems biology of microenvironmental oxidative stress and synthetic biology intervention
Funded at Albert Einstein College of Medicine · NIH-11097383 · Data updated 2026-11-12
This study is looking at how stress affects bacteria and human cells to understand why some proteins don't work properly when they're under pressure, which could help us find new ways to diagnose and treat issues related to aging and radiation damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $420,000 |
| NIH project number | 5R35GM151236-03 |
| Project ID | NIH-11097383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals affected by oxidative stress-related conditions, such as those undergoing radiation therapy or experiencing metabolic dysfunction.
✕Less likely to help
Patients with conditions unrelated to oxidative stress or those not experiencing cellular stress may not benefit from this research.
What this research studies
This research investigates the effects of oxidative stress on bacteria and human cells to uncover how certain proteins malfunction under stress conditions. By using a structural systems biology approach, the study aims to create detailed models that simulate oxidative damage and its impact on cellular metabolism. The research will involve advanced techniques like proteomics and metabolomics to validate predictions and identify potential targets for diagnosing and treating conditions related to oxidative stress, such as radiation toxicity and aging.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for conditions associated with oxidative stress.
How similar studies have gone: Previous research has shown promise in understanding oxidative stress through similar proteomic and systems biology approaches, suggesting potential for success in this study.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chang, Roger Larken — Albert Einstein College of Medicine
- Study coordinator: Chang, Roger Larken
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.