Understanding how oxidative stress affects aging and Alzheimer's disease
Official title: Analysis of oxidative stress through deep atomic embeddings
Funded at Vanderbilt University · NIH-10903311 · Data updated 2026-11-12
This study is looking at how aging and oxidative stress affect proteins in our bodies, especially in relation to Alzheimer's disease, to help us understand these changes better and find ways to improve health as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32GM154455-01 |
| Project ID | NIH-10903311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are younger and do not have any signs of cognitive decline or Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the effects of oxidative stress on the human proteome as people age, particularly in relation to Alzheimer's disease. Using advanced deep learning techniques, the study aims to create predictive models that can identify how oxidative damage modifies proteins in the body. By analyzing high-resolution protein structures, the research seeks to generate comprehensive datasets that can help clarify the mechanisms linking oxidative stress to aging-related conditions. This approach could lead to better understanding and potential interventions for diseases like Alzheimer's.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to new strategies for preventing or treating Alzheimer's disease and other age-related conditions.
How similar studies have gone: Previous research has shown promise in using computational methods to analyze protein modifications, indicating that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Bell, Eric William — Vanderbilt University
- Study coordinator: Bell, Eric William
Related research
Other NIH-funded projects on the same topics.
-
How vitamin B12 helps the gum-disease bacterium survive
Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.
-
Pancreatic beta cells, oxidative stress, and gestational diabetes
A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
-
Environmental air pollutants linked to preeclampsia risk in pregnancy
This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.
-
Oxidative stress and Nlrp3 inflammasome activation in eye lens aging
This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.
-
Glyphosate exposure and young adults' metabolic health
A study will look at how glyphosate exposure relates to metabolism and liver health in young adults, using urine measurements and health data.
-
Protein translation control in heart failure under oxidative stress
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.