Understanding how oxidative stress affects aging and Alzheimer's disease
Analysis of oxidative stress through deep atomic embeddings
This study is looking at how aging and oxidative stress affect proteins in our bodies, especially in relation to Alzheimer's disease, to help us understand these changes better and find ways to improve health as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10903311 on NIH RePORTER |
What this research studies
This research investigates the effects of oxidative stress on the human proteome as people age, particularly in relation to Alzheimer's disease. Using advanced deep learning techniques, the study aims to create predictive models that can identify how oxidative damage modifies proteins in the body. By analyzing high-resolution protein structures, the research seeks to generate comprehensive datasets that can help clarify the mechanisms linking oxidative stress to aging-related conditions. This approach could lead to better understanding and potential interventions for diseases like Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients who are younger and do not have any signs of cognitive decline or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to new strategies for preventing or treating Alzheimer's disease and other age-related conditions.
How similar studies have performed: Previous research has shown promise in using computational methods to analyze protein modifications, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Bell, Eric William — Vanderbilt University
- Study coordinator: Bell, Eric William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.