Understanding how ovulation affects ovarian cancer development
Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10992407
This study is looking at how ovulation might be linked to the development of high-grade serous ovarian cancer, which is a serious type of ovarian cancer, and it aims to find ways to prevent this cancer by understanding the role of the ovaries and fallopian tubes in the process.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10992407 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between ovulation and the development of high grade serous ovarian cancer, the most lethal form of ovarian cancer. By using advanced three-dimensional organotypic cultures that replicate the human menstrual cycle, the study aims to uncover how the ovarian microenvironment and ovulation contribute to cancer initiation. The research focuses on the fallopian tube epithelium as a potential source of ovarian cancer, exploring mechanisms that could prevent tumor growth by blocking ovulation. Patients may benefit from insights that could lead to new prevention strategies or treatments for ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women at risk for ovarian cancer, particularly those with a family history or genetic predisposition.
Not a fit: Patients with other types of cancer or those who do not have a risk for ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating high grade serous ovarian cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of ovulation in ovarian cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURDETTE, JOANNA E — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: BURDETTE, JOANNA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.