Understanding how ovarian cancer spreads from the fallopian tubes
Uncovering the Mechanisms of Metastasis in Fallopian Tube-Originated Ovarian Cancer
This study is looking into how ovarian cancer starts in the fallopian tubes and spreads, using a special mouse model to help find new ways to treat patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11076269 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the spread of ovarian cancer that originates in the fallopian tubes, particularly focusing on high-grade serous carcinomas. By utilizing a specialized mouse model that mimics human disease, researchers aim to uncover the molecular processes that lead to metastasis. The study employs advanced techniques such as single-cell RNA sequencing to identify tumor-initiating cells and their role in cancer progression. The findings could provide insights into potential new treatments for ovarian cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with high-grade serous ovarian cancer, particularly those with genetic mutations such as BRCA or p53.
Not a fit: Patients with early-stage ovarian cancer or those with other types of ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ovarian cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promise in understanding cancer metastasis through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yang-Hartwich, Yang — Yale University
- Study coordinator: Yang-Hartwich, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.