Understanding how outer hair cells in the ear amplify sound
Structural basis of Outer Hair Cell Electromotility at High Resolution
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-11089306
This study is looking at how a special protein called Prestin helps our ears amplify sound, which could lead to better understanding and treatments for hearing loss.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11089306 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind the cochlear amplifier, specifically focusing on a protein called Prestin found in outer hair cells of the cochlea. By examining how Prestin functions as a voltage-driven motor, the research aims to uncover the structural and dynamic properties that enable these cells to amplify sound. The study employs advanced techniques to visualize Prestin at high resolution, addressing fundamental questions about its role in hearing. Patients may benefit from insights gained into hearing loss and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing hearing loss or related auditory issues.
Not a fit: Patients with normal hearing or those whose hearing loss is not related to outer hair cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for hearing loss.
How similar studies have performed: While the specific approach of studying Prestin at high resolution is novel, previous research has shown success in understanding cochlear mechanics and its implications for hearing.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEROZO, EDUARDO A — UNIVERSITY OF CHICAGO
- Study coordinator: PEROZO, EDUARDO A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.