Understanding how our internal body clock influences daily behaviors and physiology
Official title: The Generation of Multi-Phasic Circadian Output
Funded at Washington University · NIH-11058529 · Data updated 2026-11-12
This study is looking at how our body's internal clock works by using fruit flies to learn more about how it keeps our daily rhythms in sync, which could help people with sleep problems and other health issues related to these rhythms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 5, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM149192-03 |
| Project ID | NIH-11058529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals experiencing sleep disorders, metabolic issues, or other health conditions influenced by circadian rhythms.
✕Less likely to help
Patients with conditions unrelated to circadian rhythms or those who do not experience any rhythm-related health issues may not receive benefit from this research.
What this research studies
This research investigates the internal circadian clock, which helps regulate various physiological processes and behaviors throughout the day and night. By studying the model organism Drosophila, or fruit flies, the research aims to uncover how different phases of the circadian clock are generated and utilized by the brain and other cells. The focus is on understanding the synchronization of pacemaker neurons that control daily rhythms, which could provide insights into how disruptions in these rhythms affect health. Patients may benefit from findings that could lead to better management of conditions influenced by circadian rhythms, such as sleep disorders and metabolic diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to circadian rhythm disruptions, enhancing overall health and well-being.
How similar studies have gone: Previous research has shown success in understanding circadian rhythms and their impact on health, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Taghert, Paul H — Washington University
- Study coordinator: Taghert, Paul H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.