Understanding How Our Genes Make Different Proteins
Genomic Analysis of Nucleic Acid Transactions
This project aims to understand how our bodies create many different proteins from a single gene, which is a key process for our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11056041 on NIH RePORTER |
What this research studies
Our bodies use a process called alternative splicing to make various proteins from the same genetic instructions. This is important for regulating how our genes work and for creating the wide variety of proteins our bodies need. This project will look closely at how certain proteins, called RNA binding proteins, control this splicing process. By learning how these proteins interact and regulate each other, we hope to gain new insights into how our cells maintain balance and function correctly.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but could eventually benefit individuals with conditions caused by errors in how genes make proteins.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge that helps us understand the root causes of diseases linked to errors in protein production.
How similar studies have performed: This project builds upon existing knowledge of gene expression and RNA biology, exploring specific regulatory mechanisms that are still not fully understood.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Graveley, Brenton R. — University of Connecticut Sch of Med/dnt
- Study coordinator: Graveley, Brenton R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.