Understanding How Our Genes Influence Health and Disease
Predicting context-specific molecular and phenotypic effects of genetic variation through the lens of the cis-regulatory code
This project aims to understand how small differences in our genes affect our health and disease risk in different parts of the body.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11105973 on NIH RePORTER |
What this research studies
Our bodies are built on a complex genetic code, and tiny changes in this code can sometimes lead to health problems. This project uses advanced lab techniques and powerful computer models to figure out how these genetic differences work. We are looking at how specific gene variations influence cells and body functions, especially in conditions affecting the brain and heart. The goal is to create a detailed map of how our genes are regulated, helping us understand why certain genetic changes lead to specific health outcomes.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals with genetic variations linked to various diseases, including those affecting the brain and heart.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could help us better understand the root causes of many diseases, leading to more targeted ways to prevent or treat them in the future.
How similar studies have performed: This project builds upon recent advancements in functional genomics and deep learning models, combining established and novel approaches to interpret genetic regulation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Kundaje, Anshul — Stanford University
- Study coordinator: Kundaje, Anshul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.