Understanding how our genes are organized and how viruses like HIV and coronaviruses work
Bridging Disparate Structural/Functional Scales: Multiscale Modeling of Genome Organization and of Viral RNA Frameshifting
This project uses advanced computer models to understand how our genetic material is organized and how viruses like HIV and coronaviruses function at a tiny level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11103229 on NIH RePORTER |
What this research studies
This project uses powerful computer simulations to explore the intricate ways our DNA is folded inside cells and how certain viruses, including those causing AIDS and COVID-19, operate. Researchers are building detailed models to see how proteins affect gene activity and how viral RNA changes shape, which is crucial for their survival. By connecting these tiny details to larger biological processes, we hope to uncover new insights into diseases like cancer and viral infections. This work aims to reveal the fundamental mechanisms that drive these conditions, paving the way for future treatments.
Who could benefit from this research
Good fit: This foundational computational biophysics project does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate clinical treatments or direct intervention would not benefit from this early-stage, computational modeling work.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of how our genes are regulated and how viruses infect cells, potentially leading to new strategies for treating cancer and viral diseases like AIDS and COVID-19.
How similar studies have performed: Computational modeling and molecular dynamics are established scientific approaches, but applying them to these specific complex biological systems at multiple scales is an ongoing and evolving area of research.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Schlick, Tamar — New York University
- Study coordinator: Schlick, Tamar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.