Understanding how our DNA stays stable to prevent cancer
Studying the mechanisms underlying the protection of common fragile sites and structure-prone DNA sequences
This research explores how our cells protect certain vulnerable parts of our DNA to prevent damage that can lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11088796 on NIH RePORTER |
What this research studies
Our DNA contains specific areas, called common fragile sites, and other unique sequences that are prone to breaking. When these breaks happen, they can contribute to the development of cancer. This project aims to uncover the natural ways our cells maintain the integrity of these delicate DNA regions. We want to understand how cells repair these breaks and coordinate different protective pathways to keep our genetic material healthy.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could eventually benefit individuals at risk for or living with cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of cancer development and potentially new strategies for cancer prevention or treatment by targeting DNA stability.
How similar studies have performed: This research builds upon existing knowledge of DNA repair and fragility, exploring specific mechanisms in a novel way.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wu, Xiaohua — Scripps Research Institute, the
- Study coordinator: Wu, Xiaohua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.