Understanding how our cells protect their genetic information during copying
Nuclear dynamics maintaining chromatin integrity during DNA replication
This work explores how our cells keep their genetic material safe and organized when they make copies, focusing on a key protein called ATR.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11110444 on NIH RePORTER |
What this research studies
Our bodies are made of tiny cells, and inside each cell is our genetic instruction book, the genome, arranged in a special 3D way. When cells divide, they need to make a perfect copy of this book, a process called DNA replication, while also reading parts of it to make proteins, called transcription. This project looks at how cells manage these two important tasks at the same time without causing conflicts that could damage our genes. Researchers are particularly interested in a protein called ATR, which seems to play a crucial role in coordinating these processes and preventing genetic errors. By understanding how ATR works, we can learn more about how cells maintain their health and prevent disease.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patient participation at this stage, but future clinical applications could benefit individuals with conditions related to DNA damage or replication errors.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us understand the fundamental causes of genetic instability, which is linked to various diseases, including cancer and certain genetic disorders.
How similar studies have performed: While the specific mechanisms of ATR in coordinating replication and transcription are still being uncovered, the role of ATR in DNA damage response is well-established through extensive prior research.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Saldivar, Joshua — Oregon Health & Science University
- Study coordinator: Saldivar, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.