Understanding how our cells detect problematic DNA
Mechanistic Studies of cytosolic double-stranded DNA sensing pathways.
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11120841
This research explores how our body's cells recognize unusual DNA inside them, which can lead to inflammation and various health problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11120841 on ClinicalTrials.gov |
What this research studies
When double-stranded DNA appears in the wrong place inside our cells, it signals a serious issue, like infection or damage. Our immune system has special sensors that detect this misplaced DNA and trigger inflammation to fight off threats. However, when these sensing pathways don't work correctly, they can contribute to many human diseases. This project aims to uncover the exact molecular steps of how these sensors are activated and regulated, and how they might mistakenly target our own body's components. Researchers will use advanced techniques like X-ray crystallography and cell-based tests to understand these processes in detail.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications could benefit individuals with autoimmune diseases or chronic inflammatory conditions.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat diseases caused by faulty immune responses to DNA, such as autoimmune conditions or chronic inflammation.
How similar studies have performed: While the general area of innate immunity is well-studied, this project aims to resolve specific, long-standing mechanistic questions, suggesting a novel approach to known challenges.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOHN, JUNGSAN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SOHN, JUNGSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.