Understanding how our body clocks affect health and disease
Genetics of human circadian rhythms: using sequencing, novel phenotyping methods, and functional assays to move towards a deeper understanding of circadian mechanisms
This study is looking at how our body's natural daily rhythms work and how problems with these rhythms might lead to health issues like cancer and metabolic disorders, so we can use this information to help improve care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10912652 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms behind human circadian rhythms, which are the natural cycles that regulate our biological functions over a 24-hour period. By analyzing genetic data and developing new methods to assess circadian behavior, the research aims to uncover how disruptions in these rhythms can lead to various health issues, including cancer and metabolic disorders. The approach includes using existing biobanks to study individuals with unique circadian patterns and creating cellular assays to test the effects of these rhythms on health. Ultimately, the goal is to integrate this knowledge into clinical care to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing circadian rhythm disorders or related health issues, such as cancer or cardiometabolic diseases.
Not a fit: Patients with stable circadian rhythms and no related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and preventative strategies for conditions linked to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms and their impact on health, suggesting that this approach has potential for significant advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lane, Jacqueline Marie — Brigham and Women's Hospital
- Study coordinator: Lane, Jacqueline Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.