Understanding how our bodies manage proteins to stay healthy as we age
Dissecting the integrated mechanisms of protein turnover to prevent proteostatic decline with aging
This research aims to understand how our bodies keep proteins healthy as we get older, which could help prevent age-related decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11103226 on NIH RePORTER |
What this research studies
As we age, our bodies sometimes struggle to keep proteins healthy, leading to a buildup of damaged proteins. Our bodies naturally replace old proteins with new ones, a process called protein turnover, which is key to staying healthy. However, there are many unanswered questions about how protein turnover changes with age and how treatments that extend lifespan affect this process. This project seeks to uncover the basic ways our cells manage proteins, hoping to find new ways to slow down age-related health issues.
Who could benefit from this research
Good fit: This foundational research is relevant to adults interested in understanding and potentially mitigating the effects of aging on their bodies.
Not a fit: Patients who are not experiencing age-related decline or those seeking immediate clinical interventions may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies and treatments to maintain protein health and slow down the effects of aging on our bodies.
How similar studies have performed: Previous studies have shown conflicting findings regarding protein turnover and aging, indicating this research addresses fundamental contradictions in the field.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Miller, Benjamin Francis — Oklahoma Medical Research Foundation
- Study coordinator: Miller, Benjamin Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.