Understanding How Our Bodies Heal Wounds
CD74 and Wound Healing
This project explores how a specific signal in our body, called CD74, helps the lining of our intestines heal after injury or illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11089318 on NIH RePORTER |
What this research studies
Many conditions like surgery, infections, or inflammatory bowel diseases can damage the protective lining of our intestines. Our bodies need to repair this lining quickly to stay healthy. This research looks closely at a natural healing process involving a protein called CD74, which acts like a signal for cells to regenerate. We are trying to understand how this CD74 signal is activated, if we can safely boost its activity, and how individual genetic differences might affect its healing power.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone experiencing conditions that damage the intestinal lining, such as inflammatory bowel disease, or those recovering from surgery, radiation, or chemotherapy.
Not a fit: Patients seeking immediate new treatments or direct participation in a clinical trial may not find direct benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help patients heal faster and more effectively from various gut injuries and conditions.
How similar studies have performed: This project builds upon recent discoveries about CD74's role in intestinal healing, suggesting a promising path forward.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Moonah, Shannon — University of Florida
- Study coordinator: Moonah, Shannon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.