Understanding how our bodies defend against infections from microbes.
Evolution of innate antiviral defense mechanisms and other microbe-driven genetic innovations
This study looks at how our immune system changes to fight off infections and how germs adapt to get around our defenses, helping us understand our own immune responses better and possibly leading to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10842676 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between humans and pathogens, focusing on how our immune system evolves to protect us from infections. By examining the genetic variations in both hosts and microbes, the study aims to identify key genes and mechanisms that enhance our defenses against diseases. The research utilizes an evolutionary perspective to explore how pathogens adapt to overcome our immune responses, which could lead to new insights into susceptibility to infections. Patients may benefit from a better understanding of their own immune responses and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of recurrent infections or those interested in understanding their genetic susceptibility to diseases.
Not a fit: Patients with non-infectious diseases or those not affected by microbial infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating infectious diseases.
How similar studies have performed: Previous research has shown success in understanding host-pathogen interactions, making this approach promising for uncovering new insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Daugherty, Matthew — University of California, San Diego
- Study coordinator: Daugherty, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.