Understanding how our bodies control important cell processes
Regulation of rRNA transcription in mammalian tissues
This research explores how our cells make essential building blocks, called ribosomal RNAs, and how problems in this process can lead to illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11091206 on NIH RePORTER |
What this research studies
Our cells rely on ribosomal RNAs (rRNAs) to function correctly, and different cell types need different amounts of these rRNAs. When the production of rRNAs is not precisely controlled, it can contribute to various diseases. This project uses advanced tools to map out how cells regulate rRNA production across different tissues. The main goal is to uncover the complex mechanisms that ensure precise rRNA levels, which are vital for maintaining healthy cell identity and function.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation at this stage, so there are no specific patient qualifications.
Not a fit: Patients seeking immediate new treatments would not directly benefit from this basic science research, as it focuses on fundamental biological understanding.
Why it matters
Potential benefit: If successful, this foundational research could reveal new insights into the basic mechanisms of disease and potentially identify new targets for future treatments.
How similar studies have performed: While the regulation of other RNA types is well-studied, the control of ribosomal RNA, the focus of this work, has been largely overlooked, making this approach novel in its depth.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Paralkar, Vikram R. — University of Pennsylvania
- Study coordinator: Paralkar, Vikram R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.