Understanding how Otopetrin proton channels work in cells
Cellular physiology of Otopetrin Proton Channels
This study is looking at a new group of channels in our cells that help control acidity and other important functions, which could help us understand how they work in both animals and humans, especially in the digestive system, and how this knowledge might help with certain health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11005292 on NIH RePORTER |
What this research studies
This research investigates a newly discovered family of proton-selective ion channels known as Otopetrins, focusing on their roles in various biological processes, including pH sensing and biomineralization. The study aims to explore the functional properties and distribution of these channels in both vertebrates and invertebrates, particularly OTOP2 and OTOP3. By employing multidisciplinary approaches, the research seeks to uncover how these channels contribute to cellular functions and their potential implications in disease prognosis. Patients may benefit from insights gained about the role of these channels in the digestive tract and other systems.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to digestive tract function or diseases associated with pH imbalance.
Not a fit: Patients with conditions unrelated to cellular ion channels or digestive health may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cellular processes that may improve disease prognosis and treatment strategies.
How similar studies have performed: Other research has shown promise in understanding ion channels and their roles in cellular functions, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Liman, Emily R. — University of Southern California
- Study coordinator: Liman, Emily R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.