Understanding how Otopetrin proton channels work in cells
Official title: Cellular physiology of Otopetrin Proton Channels
Funded at University of Southern California · NIH-11005292 · Data updated 2026-11-12
This study is looking at a new group of channels in our cells that help control acidity and other important functions, which could help us understand how they work in both animals and humans, especially in the digestive system, and how this knowledge might help with certain health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $371,250 |
| NIH project number | 5R35GM152051-02 |
| Project ID | NIH-11005292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to digestive tract function or diseases associated with pH imbalance.
✕Less likely to help
Patients with conditions unrelated to cellular ion channels or digestive health may not receive any benefit from this research.
What this research studies
This research investigates a newly discovered family of proton-selective ion channels known as Otopetrins, focusing on their roles in various biological processes, including pH sensing and biomineralization. The study aims to explore the functional properties and distribution of these channels in both vertebrates and invertebrates, particularly OTOP2 and OTOP3. By employing multidisciplinary approaches, the research seeks to uncover how these channels contribute to cellular functions and their potential implications in disease prognosis. Patients may benefit from insights gained about the role of these channels in the digestive tract and other systems.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cellular processes that may improve disease prognosis and treatment strategies.
How similar studies have gone: Other research has shown promise in understanding ion channels and their roles in cellular functions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Liman, Emily R. — University of Southern California
- Study coordinator: Liman, Emily R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.