Understanding how osteoporosis treatments work and why they may stop being effective.
Official title: Admin Core
Funded at Massachusetts General Hospital · NIH-11085954 · Data updated 2026-11-12
This study is looking into how osteoporosis treatments work and why they might not be as effective over time, with the goal of finding better ways to help people with osteoporosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $148,987 |
| NIH project number | 5P50AR080596-03 |
| Project ID | NIH-11085954 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with osteoporosis who are currently receiving or have received anabolic therapies.
✕Less likely to help
Patients who do not have osteoporosis or those who are not undergoing anabolic therapy may not benefit from this research.
What this research studies
This research aims to uncover the mechanisms behind osteoporosis anabolic therapies and why their effectiveness diminishes over time. By collaborating with a network of experts from prestigious institutions, the project will focus on the cellular and molecular actions of these treatments in humans. The Administrative Core will facilitate patient recruitment and support the scientific efforts of the research team, ensuring that findings are effectively communicated and utilized. Patients may be engaged in the process to help improve treatment strategies for osteoporosis.
Why it matters
Potential benefit: If successful, this research could lead to improved osteoporosis treatments that remain effective over time.
How similar studies have gone: Previous research has shown promise in understanding osteoporosis treatments, but this project aims to provide deeper insights into their mechanisms, making it a significant advancement in the field.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Wein, Marc Nathan — Massachusetts General Hospital
- Study coordinator: Wein, Marc Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.